Spatially resolved transcriptomics has enabled precise genome-wide mRNA expression
profiling within tissue sections. The performance of methods targeting the polyA tails of …

Medulloblastomas, highly aggressive neoplasms of the central nervous system (CNS) that
present significant heterogeneity in clinical presentation, disease course, and treatment …

Medulloblastoma (MB) is considered the commonest malignant brain tumor in children.
Multimodal treatments consisting of surgery, radiation, and chemotherapy have improved …

This study reevaluates the conventional understanding of midbrain anatomy and
neuroanatomical nomenclature in the context of recent genetic and anatomical discoveries …

The zinc-finger transcription factor GLI2 is frequently amplified in childhood
medulloblastoma of the Sonic-hedgehog type (SHH-MB), with or without amplification of …

Simple Summary MYC is a well-described oncogene across multiple cancer types. In
medulloblastoma (MB), significance is subtype-dependent and associated with a particularly …

Simple Summary Medulloblastoma (MB) is the most common malignant brain tumor in
children and has a dismal prognosis. A challenge with MB is identifying patients who could …

Background Maximizing surgical resection of medulloblastoma (MB) impacts overall
survival; nevertheless, surgical resection remains a challenge since the infiltrative behavior …

Medulloblastoma (MB) is the most common childhood tumor with a poor prognosis. Primary
approaches for treating MB comprise surgical resection along with radiotherapy and …

Medulloblastoma, the most common malignant brain tumor in children, presents a complex
treatment challenge due to its propensity for infiltrative growth within the posterior fossa and …