A better understanding of COVID-19 in people with primary immunodeficiency (PI), rare
inherited defects in the immune system, is important for protecting this population, especially …

Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune
host defense and immunoregulation. Considering the predisposition to develop severe and …

Breakthrough SARS-CoV-2 infections in fully vaccinated individuals are considered a
consequence of waning immunity. Serum antibodies represent the most measurable …

The overall success of worldwide mass vaccination in limiting the negative effect of the
COVID-19 pandemics is inevitable, however, recent SARS-CoV-2 variants of concern …

Background: Patients with primary antibody deficiencies are at risk in the current COVID-19
pandemic due to their impaired response to infection and vaccination. Specifically, patients …

CVID patients have an increased susceptibility to vaccine-preventable infections. The
question on the potential benefits of immunization of CVID patients against SARS-CoV-2 …

Since the arrival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in
December 2019, its characterization as a novel human pathogen, and the resulting …

Morbidity and mortality of COVID-19 is increased in patients with inborn errors of immunity
(IEI). Age and comorbidities and also impaired type I interferon immunity were identified as …

Background Individuals with primary and secondary immunodeficiency (PID/SID) were
shown to be at risk of poor outcomes during the early stages of the SARS-CoV-2 pandemic …

Background Patients with primary and secondary antibody deficiency are vulnerable to
COVID-19 and demonstrate diminished responses following two-dose SARS-CoV-2 vaccine …