In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …

INTRODUCTION DNA methylation is essential to mammalian development, and
dysregulation can cause serious pathological conditions, including immunodeficiency …

Background: DNA methylation is a form of epigenetic modification that has been shown to
play a significant role in gene regulation. In cancer, DNA methylation plays an important role …

This study investigates aberrant DNA methylations as potential diagnosis and prognosis
markers for esophageal squamous-cell carcinoma (ESCC), which if diagnosed at advanced …

Homeobox (HOX) transcription factors, encoded by a subset of homeodomain superfamily
genes, play pivotal roles in many aspects of cellular physiology, embryonic development …

DNA methylation is tightly regulated during development and is stably maintained in healthy
cells. In contrast, cancer cells are commonly characterized by a global loss of DNA …

Clonal hematopoiesis is a prevalent age-related condition associated with a greatly
increased risk of hematologic disease; mutations in DNA methyltransferase 3A (DNMT3A) …

Breast cancer develops in the mammary glands during mammalian adulthood and is
considered the second most common type of human carcinoma and the most incident and …