Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact
In chronic obstructive pulmonary disease (COPD), exacerbations (ECOPD), characterized
by an acute deterioration in respiratory symptoms, are fundamental events impacting …
by an acute deterioration in respiratory symptoms, are fundamental events impacting …
Inflammatory endotypes in COPD
PJ Barnes - Allergy, 2019 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a major global health problem that is
poorly treated by current therapies as it has proved difficult to treat the underlying …
poorly treated by current therapies as it has proved difficult to treat the underlying …
Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised …
Background Evidence is scarce on the relative risk-benefit of inhaled triple therapy,
consisting of inhaled corticosteroid, long-acting muscarinic antagonist, and long-acting β 2 …
consisting of inhaled corticosteroid, long-acting muscarinic antagonist, and long-acting β 2 …
Inhaled corticosteroids in COPD: friend or foe?
The efficacy, safety and positioning of inhaled corticosteroids (ICS) in the treatment of
patients with chronic obstructive pulmonary disease (COPD) is much debated, since it can …
patients with chronic obstructive pulmonary disease (COPD) is much debated, since it can …
Susceptibility to exacerbation in COPD
We welcome the report by the SPIROMICS investigators in The Lancet Respiratory
Medicine, 1 repeating our 2010 ECLIPSE analysis2 describing exacerbations in chronic …
Medicine, 1 repeating our 2010 ECLIPSE analysis2 describing exacerbations in chronic …
Long-term triple therapy de-escalation to indacaterol/glycopyrronium in patients with chronic obstructive pulmonary disease (SUNSET): a randomized, double-blind …
KR Chapman, JR Hurst, SM Frent, M Larbig… - American journal of …, 2018 - atsjournals.org
Rationale: There are no studies on withdrawal of inhaled corticosteroids in patients on long-
term triple therapy in the absence of frequent exacerbations. Objectives: To evaluate the …
term triple therapy in the absence of frequent exacerbations. Objectives: To evaluate the …
[HTML][HTML] Prognostic risk factors for moderate-to-severe exacerbations in patients with chronic obstructive pulmonary disease: a systematic literature review
Background Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity
and mortality worldwide. COPD exacerbations are associated with a worsening of lung …
and mortality worldwide. COPD exacerbations are associated with a worsening of lung …
Evidence for exacerbation-prone asthma and predictive biomarkers of exacerbation frequency
Rationale: Cross-sectional studies suggest an exacerbation-prone asthma (EPA) phenotype
and the utility of blood eosinophils and plasma IL-6 as predictive biomarkers. Objectives: To …
and the utility of blood eosinophils and plasma IL-6 as predictive biomarkers. Objectives: To …
Natural history of chronic obstructive pulmonary disease exacerbations in a general practice–based population with chronic obstructive pulmonary disease
Rationale: Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) are
important adverse events in the natural history of chronic obstructive pulmonary disease …
important adverse events in the natural history of chronic obstructive pulmonary disease …
[HTML][HTML] Understanding the impact of chronic obstructive pulmonary disease exacerbations on patient health and quality of life
Exacerbations of chronic obstructive pulmonary disease (COPD) represent a significant
clinical problem, and are associated with decreased lung function, worsening quality of life …
clinical problem, and are associated with decreased lung function, worsening quality of life …