Carcinogenic N-nitrosamine contamination in certain drugs has recently caused great
concern and the attention of regulatory agencies. These carcinogens—widely detectable in …

Acetaldehyde is a mutagen and carcinogen which occurs widely in the human environment,
sometimes in considerable amounts, but little is known about its reactions with DNA. In this …

The tobacco specific carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
and N '-nitrosonornicotine (NNN) are metabolically activated to 4-oxo-4-(3-pyridyl)-1 …

DNA damage plays a significant role in mutagenesis, carcinogenesis and ageing. Chemical
transformations leading to DNA damage include reactions of the base units with agents of …

Acetaldehyde is an environmentally widespread genotoxic aldehyde present in tobacco
smoke, vehicle exhaust and several food products. Endogenously, acetaldehyde is …

This paper summarizes our recent studies on adducts produced in the reactions of the
carcinogens crotonaldehyde (2-butenal) and acetaldehyde with deoxyguanosine (dG) and …

N-nitrosopiperidine (NPIP) is a potent esophageal carcinogen in rats whereas structurally
similar N-nitrosopyrrolidine (NPYR) induces liver, but not esophageal tumors. NPIP is a …

Previous studies have demonstrated that the reaction of crotonaldehyde with DNA produces
Michael addition products, and these have been detected in human tissues as well as …

People who use tobacco products are exposed to considerable amounts of N '-
nitrosonornicotine (NNN), a well-established esophageal carcinogen in rats. NNN is …

Neutral hydrolysis and LC− MS/MS analysis of 6-nm-thick DNA− polyion films used in
voltammetric genotoxicity screening sensors showed that concentrations of N7− guanine …