The thymus is the crucial tissue where thymocytes develop from hematopoietic precursors
that originate from the bone marrow and differentiate to generate a repertoire of mature T …

Abstract Background Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic
insulin-producing β cells are specifically destroyed by the immune system. Understanding …

Advances in modern medicine have enabled a rapid increase in lifespan and, consequently,
have highlighted the immune system as a key driver of age-related disease. Immune …

Recent technological advances have transformed our understanding of the human thymus.
Innovations such as high-resolution imaging, single-cell omics, and organoid cultures …

Background Systemic therapy is the primary treatment for advanced thymic malignancies.
However, there is an urgent need to improve clinical outcome. Personalized treatment …

The intestine hosts the largest immune cell compartment in the body as a result of its
continuous exposure to exogenous antigens. The intestinal barrier is formed by a single …

T cell development relies on a supportive epithelial microenvironment. Embryonic and
postnatal epithelial progenitors have been identified in mice, but not humans. In this issue of …

The thymus represents a primary organ of the immune system, harboring the generation and
maturation of T lymphocytes. Starting from childhood, the thymus undergoes involution …

The mouse genome has a high degree of homology with the human genome, and its
physiological, biochemical, and developmental regulation mechanisms are similar to those …

The thymus is a primary lymphoid organ playing a crucial role in immune tolerance, by
educating thymocytes through a selection mediated by thymic epithelial cells (TEC). Recent …