Progress in and promise of bacterial quorum sensing research

M Whiteley, SP Diggle, EP Greenberg - Nature, 2017 - nature.com
This Review highlights how we can build upon the relatively new and rapidly developing
field of research into bacterial quorum sensing (QS). We now have a depth of knowledge …

Quorum-sensing systems as targets for antivirulence therapy

T Defoirdt - Trends in microbiology, 2018 - cell.com
The development of novel therapies to control diseases caused by antibiotic-resistant
pathogens is one of the major challenges we are currently facing. Many important plant …

Pseudomonas aeruginosa Biofilms: Host Response and Clinical Implications in Lung Infections

NM Maurice, B Bedi, RT Sadikot - American journal of respiratory …, 2018 - atsjournals.org
Pseudomonas aeruginosa is a major health challenge that causes recalcitrant multidrug-
resistant infections, especially in immunocompromised and hospitalized patients. P …

Bacterial quorum sensing during infection

S Azimi, AD Klementiev, M Whiteley… - Annual review of …, 2020 - annualreviews.org
Bacteria are highly interactive and possess an extraordinary repertoire of intercellular
communication and social behaviors, including quorum sensing (QS). QS has been studied …

Evolution of the Pseudomonas aeruginosa quorum-sensing hierarchy

M Kostylev, DY Kim, NE Smalley… - Proceedings of the …, 2019 - National Acad Sciences
The bacterial pathogen Pseudomonas aeruginosa activates expression of many virulence
genes in a cell density-dependent manner by using an intricate quorum-sensing (QS) …

Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors

SAKS Ahmed, M Rudden, TJ Smyth… - Applied microbiology …, 2019 - Springer
At present, anti-virulence drugs are being considered as potential therapeutic alternatives
and/or adjuvants to currently failing antibiotics. These drugs do not kill bacteria but inhibit …

Molecular mechanisms and applications of N-acyl homoserine lactone-mediated quorum sensing in bacteria

L Kumar, SKS Patel, K Kharga, R Kumar, P Kumar… - Molecules, 2022 - mdpi.com
Microbial biodiversity includes biotic and abiotic components that support all life forms by
adapting to environmental conditions. Climate change, pollution, human activity, and natural …

Evolution of lasR mutants in polymorphic Pseudomonas aeruginosa populations facilitates chronic infection of the lung

K Zhao, X Yang, Q Zeng, Y Zhang, H Li, C Yan… - Nature …, 2023 - nature.com
Chronic infection with the bacterial pathogen Pseudomonas aeruginosa often leads to
coexistence of heterogeneous populations carrying diverse mutations. In particular, loss-of …

The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone …

S Mukherjee, D Moustafa, CD Smith… - PLoS …, 2017 - journals.plos.org
Quorum sensing (QS) is a bacterial cell-to-cell communication process that relies on the
production, release, and response to extracellular signaling molecules called autoinducers …

How Bacterial Adaptation to Cystic Fibrosis Environment Shapes Interactions Between Pseudomonas aeruginosa and Staphylococcus aureus

L Camus, P Briaud, F Vandenesch… - Frontiers in …, 2021 - frontiersin.org
Pseudomonas aeruginosa and Staphylococcus aureus are the two most prevalent bacteria
species in the lungs of cystic fibrosis (CF) patients and are associated with poor clinical …