Chronic intermittent hypoxia in obstructive sleep apnea: a narrative review from pathophysiological pathways to a precision clinical approach

G Labarca, J Gower, L Lamperti, J Dreyse… - Sleep and …, 2020 - Springer
Obstructive sleep apnea syndrome (OSAS) is a prevalent condition caused by dynamic
upper airway collapse during sleep. The pathological impact and consequences are due to …

Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature

CM Hoyos, KL Melehan, PY Liu, RR Grunstein… - Sleep medicine …, 2015 - Elsevier
Endothelial dysfunction is characterized by impaired endothelium-dependent vasodilatation
and is an independent predictor of adverse cardiovascular consequences. The ease with …

Exosomal miRNAs as potential biomarkers of cardiovascular risk in children

A Khalyfa, D Gozal - Journal of translational medicine, 2014 - Springer
Intercellular interactions are essential for basic cellular activities and errors in either
receiving or transferring these signals have shown to cause pathological conditions. These …

Chemoreflexes, sleep apnea, and sympathetic dysregulation

MP Mansukhani, T Kara, SM Caples… - Current hypertension …, 2014 - Springer
Obstructive sleep apnea (OSA) and hypertension are closely linked conditions. Disordered
breathing events in OSA are characterized by increasing efforts against an occluded airway …

Effect on intermittent hypoxia on plasma exosomal micro RNA signature and endothelial function in healthy adults

A Khalyfa, C Zhang, AA Khalyfa, GE Foster… - Sleep, 2016 - academic.oup.com
Abstract Study Objective: Intermittent hypoxia (IH) is associated with increased risk of
cardiovascular disease. Exosomes are secreted by most cell types and released in …

Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway

F Zhao, Y Meng, Y Wang, S Fan, Y Liu… - Frontiers in …, 2022 - frontiersin.org
Vascular endothelial dysfunction (VED) is linked with the pathogenesis of obstructive sleep
apnea (OSA) comorbidities, such as cardiovascular disease. Astragaloside IV (As-IV) has …

[HTML][HTML] Left ventricular remodeling and dysfunction in obstructive sleep apnea: Systematic review and meta-analysis

L Yu, H Li, X Liu, J Fan, Q Zhu, J Li, J Jiang, J Wang - Herz, 2020 - ncbi.nlm.nih.gov
Background Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular
mortality and morbidity. Several studies have reported that it affects the left ventricle; …

Molecular biomarkers of vascular dysfunction in obstructive sleep apnea

E Kaczmarek, JP Bakker, DN Clarke, E Csizmadia… - PLoS one, 2013 - journals.plos.org
Untreated and long-lasting obstructive sleep apnea (OSA) may lead to important vascular
abnormalities, including endothelial cell (EC) dysfunction, hypertension, and …

Baroreflex and chemoreflex controls of sympathetic activity following intermittent hypoxia

CS Freet, JF Stoner, X Tang - Autonomic Neuroscience, 2013 - Elsevier
There is a large amount of evidence linking obstructive sleep apnea (OSA), and the
associated intermittent hypoxia that accompanies it, with the development of hypertension …

Apneic sleep, insufficient sleep, and hypertension

MP Mansukhani, N Covassin, VK Somers - Hypertension, 2019 - Am Heart Assoc
Animal studies have demonstrated an increase in BP with repeated upper airway closure
and intermittent hypoxia. 25–28 Studies of human subjects have demonstrated increased …