Therapeutic effects of green tea polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and …

D Mokra, M Joskova, J Mokry - International journal of molecular sciences, 2022 - mdpi.com
(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea.
Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways …

Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages

A Marrocco, LA Ortiz - Frontiers in immunology, 2022 - frontiersin.org
In the lungs, macrophages constitute the first line of defense against pathogens and foreign
bodies and play a fundamental role in maintaining tissue homeostasis. Activated …

Early identification, accurate diagnosis, and treatment of silicosis

T Li, X Yang, H Xu, H Liu - Canadian respiratory journal, 2022 - Wiley Online Library
Silicosis is a global problem, and it has brought about great burdens to society and patients'
families. The etiology of silicosis is clear, preventable, and controllable, but the onset is …

A toxicological profile of silica nanoparticles

JY Liu, CM Sayes - Toxicology Research, 2022 - academic.oup.com
Humans are regularly exposed to silica nanoparticles in environmental and occupational
contexts, and these exposures have been implicated in the onset of adverse health effects …

Green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG): a time for a new player in the treatment of respiratory diseases?

D Mokra, J Adamcakova, J Mokry - Antioxidants, 2022 - mdpi.com
(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a
wide variety of actions. EGCG acts as a strong antioxidant which effectively scavenges …

Global incidence, prevalence and disease burden of silicosis: 30 years' overview and forecasted trends

X Liu, Q Jiang, P Wu, L Han, P Zhou - BMC Public Health, 2023 - Springer
Background Globally, silicosis accounts for 90% of all pneumoconiosis cases and is a
serious public health issue. It is characterized by progressive inflammation and irreversible …

[HTML][HTML] Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis

JC Cooley, N Javkhlan, JA Wilson, DG Foster… - JCI insight, 2023 - ncbi.nlm.nih.gov
Patients with progressive fibrosing interstitial lung diseases (PF-ILDs) carry a poor prognosis
and have limited therapeutic options. A hallmark feature is fibroblast resistance to apoptosis …

[HTML][HTML] Apelin prevents and alleviates crystalline silica-induced pulmonary fibrosis via inhibiting transforming growth factor beta 1-triggered fibroblast activation

J Shen, J Feng, Z Wu, Y Ou, Q Zhang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Silicosis is a common and ultimately fatal occupational disease, yet the limited therapeutic
option remains the major clinical challenge. Apelin, an endogenous ligand of the G-protein …

Progressive massive fibrosis: An overview of the recent literature

DN Weissman - Pharmacology & therapeutics, 2022 - Elsevier
This review provides an overview of literature addressing progressive massive fibrosis
(PMF) from September 2009 to the present. Advances are described in understanding its …

Modifiable risk factors linked to the development of rheumatoid arthritis: evidence, immunological mechanisms and prevention

JA Maisha, HS El-Gabalawy, LJ O'Neil - Frontiers in Immunology, 2023 - frontiersin.org
Rheumatoid Arthritis (RA) is a common autoimmune disease that targets the synovial joints
leading to arthritis. Although the etiology of RA remains largely unknown, it is clear that …