Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of
death in the United States. Hepatocyte steatosis is a component of metabolic syndrome and …

Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic
steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding …

Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can
progress to liver fibrosis. Recent clinical advance suggests a reversibility of liver fibrosis, but …

Tissue-resident and recruited macrophages contribute to both host defense and pathology.
Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep …

Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …

Macrophages regulate tissue regeneration following injury. They can worsen tissue injury by
producing reactive oxygen species and other toxic mediators that disrupt cell metabolism …

Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …

Sustained hepatic inflammation is an important factor in progression of chronic liver
diseases, including hepatitis C or non-alcoholic steatohepatitis. Liver inflammation is …

Acute and acute-on-chronic liver failure (ALF and ACLF), though distinct clinical entities, are
considered syndromes of innate immune dysfunction. Patients with ALF and ACLF display …