Simple Summary Despite the adoption of aggressive, multimodal treatment schedules, the
cure rate of high-grade osteosarcoma (HGOS) has not significantly improved in the last 30 …

Osteosarcoma is the most common primary tumor of bone. Approximately 2/3 of patients
who present with localized osteosarcoma can be expected to be cured of their disease with …

Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of
cancer-related death in children and adolescents. Although long-term survival in localized …

Bioorthogonal catalysis via transition metal catalysts (TMCs) enables the generation of
therapeutics locally through chemical reactions not accessible by biological systems. This …

Osteosarcoma is the most common primary malignant bone tumor in children and
adolescents, with highly aggressive behavior and early systemic metastasis. The survival …

Osteosarcoma, a bone cancer most commonly seen in adolescents and young adults, is
usually a high-grade malignancy characterized by a very high risk for the development of …

Osteosarcoma (OS) is one of the most common malignant tumors derived from
mesenchymal tissue and is highly invasive, mainly in children and adolescents. Treatment of …

Background Neoadjuvant chemotherapy improves outcome in osteosarcoma. Determination
of optimum regimens for survival, toxicity and prognostic factors requires randomised …

The nitrogen mustards are powerful cytotoxic and lymphoablative agents and have been
used for more than 60 years. They are employed in the treatment of cancers, sarcomas, and …

Localized cancer treatments with combination drugs have recently emerged as crucial
approaches for effective inhibition of tumor growth and reoccurrence. In this study, we …