Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people
today. The search for new treatments is made ever more urgent by prospects for increasing …

Adult neurogenesis is the creation of new neurons which integrate into the existing neural
circuit of the adult brain. Recent evidence suggests that adult hippocampal neurogenesis …

Transgenic mice expressing human amyloid precursor proteins (hAPP) and amyloid-β
peptides (Aβ) in neurons develop phenotypic alterations resembling Alzheimer's disease …

Transgenic mice made by crossing animals expressing mutant amyloid precursor protein
(APPswe) to mutant presenilin 1 (PS1dE9) allow for incremental increases in Aβ42 …

Mice co‐expressing the Swedish amyloid precursor protein mutation (APPSwe) and exon 9
deletion (ΔE9) of the PSEN1 gene begin to develop amyloid plaques at 6–7 months of age …

Background Inflammation is associated with Aβ pathology in Alzheimer's disease (AD) and
transgenic AD models. Previously, it has been demonstrated that chronic stimulation of the …

The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …

In humans, heterogeneity in the decline of hippocampal-dependent episodic memory is
observed during aging. Rodents have been employed as models of age-related cognitive …

Alzheimer's disease (AD) is the most common neurodegenerative affliction of the elderly,
presenting with progressive memory loss and dementia and terminating with death. There …

The Tg2576 mouse model of Alzheimer's disease (AD) exhibits age-dependent amyloid β
(Aβ) deposition in the brain. We studied electroencephalographically defined sleep and the …