Role of intracardiac renin-angiotensin-aldosterone system in extracellular matrix remodeling.

PJ Lijnen, VV Petrov - Methods and findings in experimental and …, 2003 - europepmc.org
Functional angiotensin II receptors have been documented in cardiac fibroblasts as well as
an intracardiac aldosterone system that responds to short-and long-term physiological …

Change in diastolic left ventricular filling after one year of antihypertensive treatment: The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study

K Wachtell, JN Bella, J Rokkedal, V Palmieri… - Circulation, 2002 - Am Heart Assoc
Background—It is well established that hypertensive patients with left ventricular (LV)
hypertrophy have impaired diastolic filling. However, the impact of antihypertensive …

Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats

J Joseph, L Joseph, NS Shekhawat… - American Journal …, 2003 - journals.physiology.org
A recent report indicated that hyperhomocysteinemia (Hhe), in addition to its
atherothrombotic effects, exacerbates the adverse cardiac remodeling seen in response to …

Induction of cardiac fibrosis by angiotensin II.

PJ Lijnen, VV Petrov, RH Fagard - Methods and findings in …, 2000 - europepmc.org
The possible contributions of the angiotensin receptor subtypes 1 (AT1) and 2 (AT2) to
angiotensin II-induced changes in collagen secretion and production were studied using the …

Angiotensin II stimulates hyperplasia but not hypertrophy in immature ovine cardiomyocytes

NC Sundgren, GD Giraud, PJS Stork… - The Journal of …, 2003 - Wiley Online Library
Rat and sheep cardiac myocytes become binucleate as they complete the 'terminal
differentiation'process soon after birth and are not able to divide thereafter. Angiotensin II …

Antagonism of the renin-angiotensin system, hypertrophy and gene expression in cardiac myocytes.

P Lijnen, V Petrov - Methods and findings in experimental and …, 1999 - europepmc.org
In response to humoral and mechanical stimuli, the myocardium adapts to increased work
load through hypertrophy of individual muscle cells. Myocardial hypertrophy is characterized …

Irbesartan reduces QT dispersion in hypertensive individuals

PO Lim, M Nys, AAO Naas, AD Struthers… - …, 1999 - Am Heart Assoc
Angiotensin type 1 receptor antagonists have direct effects on the autonomic nervous
system and myocardium. Because of this, we hypothesized that irbesartan would reduce QT …

Эффективность методов функциональной коррекции у больных стенокардией напряжения и гипертонической болезнью

ОД Лебедева, СН Кобельков, ДУ Усмонзода… - Вестник …, 2009 - elibrary.ru
В статье анализируются данные по применению корригирующих технологий
восстановительной медицины при стабильной стенокардии напряжения II …

Effect of hypertension on angiotensin-(1–7) levels in rats with different angiotensin-I converting enzyme polymorphism

MP Ocaranza, C Palomera, M Román, J Bargetto… - Life sciences, 2006 - Elsevier
To determine circulating angiotensin-(1–7)[Ang-(1, 7)] levels in rats with different
angiotensin converting enzyme (ACE) genotypes and to evaluate the effect of hypertension …

Antagonism of the renin-angiotensin-aldosterone system and collagen metabolism in cardiac fibroblasts.

P Lijnen, V Petrov - Methods and findings in experimental and …, 1999 - europepmc.org
The renin-angiotensin-aldosterone system has emerged as a potential candidate for the
accumulation of collagen in cardiac fibroblasts. The traditional renin-angiotensin …