The nitroimidazole antibiotic metronidazole has a limited spectrum of activity that
encompasses various protozoans and most Gram-negative and Gram-positive anaerobic …

Clostridium perfringens is the causative agent of a number of human diseases, such as gas
gangrene and food poisoning, and many diseases of animals. Recently significant advances …

Over 12 years, 136 episodes of bacteremia caused by clostridial species were documented.
Eighty‐three were monomicrobial, and 53 were polymicrobial. Gastrointestinal …

Synopsis Imipenem is the first available semisynthetic thienamycin and is administered
intravenously in combination with cilastatin, 1 a renal dipeptidase inhibitor that increases …

Gas gangrene caused by Clostridium perfringens is associated with significant mortality and
morbidity in spite of penicillin treatment. Although prompt surgical debridement has been …

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The treatment of experimental gas gangrene caused by Clostridium perfringens was
investigated by using combinations of antimicrobial agents. This study demonstrated that …

A 55-year-old woman with stage IV-B nodular sclerosing Hodgkin's lymphoma presented to
the emergency department with fever and lethargy of 12 hours' duration. The patient …

Twelve clinical and 102 fecal isolates from healthy carriers of Clostridium perfringens type A
were tested for virulence in juvenile, outbred NMRI mice (intramuscular route). There were …

Five antimicrobial drugs (ciprofloxacin, clindamycin, imipenem, penicillin G, and rifampin)
were examined for therapeutic efficacy in a murine model gas gangrene due to Clostridium …