Low nephron number—resulting, for example, from prematurity or developmental anomalies—
is a risk factor for the development of hypertension, chronic kidney disease and kidney …

Eya1 is critical for establishing and maintaining nephron progenitor cells (NPCs). It belongs
to a family of proteins called phosphatase-transcriptional activators but without intrinsic DNA …

The vertebrate Six1 and Six2 arose by gene duplication from the Drosophila sine oculis and
have since diverged in their developmental expression patterns. Both genes are expressed …

SMARCA2 and SMARCA4 are the ATPases of the SWI/SNF chromatin remodeling complex,
which play a significant role in regulating transcriptional activity and DNA repair in cells …

Pre-B-cell leukemia homeobox transcription factor 1 (PBX1) is a member of the TALE (three-
amino acid loop extension) family and functions as a homeodomain transcription factor (TF) …

Aims Diabetic nephropathy (DN) is one of the most common complications of diabetes and
represents a prototypical form of chronic kidney disease (CKD). Interstitial fibrosis is a key …

The association between ear and kidney anomalies has long been recognized. However,
little is known about the underlying mechanisms. In the last two decades, embryonic …

Members of the Eya family, which are a class of transcription factors with phosphatase
activity, are widely expressed in cranial sensory organs during development. However, it is …

Parkinson's disease (PD) is a neurodegenerative disease characterized by selective loss of
dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). We recently …

Parkinson's disease (PD) is a severe neurodegenerative disease associated with the loss of
dopaminergic (DA) neurons in the substantia nigra (SN). Although its pathogenesis remains …