Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy
Brain microglia (MG) may serve as a human immunodeficiency virus 1 (HIV) reservoir and
ignite rebound viremia following cessation of antiretroviral therapy (ART), but they have yet …
ignite rebound viremia following cessation of antiretroviral therapy (ART), but they have yet …
Drugs of abuse and their impact on viral pathogenesis
JT Blackard, KE Sherman - Viruses, 2021 - mdpi.com
Commonly misused substances such as alcohol, cocaine, heroin, methamphetamine, and
opioids suppress immune responses and may impact viral pathogenesis. In recent years …
opioids suppress immune responses and may impact viral pathogenesis. In recent years …
Beyond the Syndemic of Opioid Use Disorders and HIV: The Impact of Opioids on Viral Reservoirs
M Trunfio, A Chaillon, N Beliakova-Bethell, R Deiss… - Viruses, 2023 - mdpi.com
People with HIV are more likely to have opioid use disorder and to be prescribed opioids for
chronic pain than the general population; however, the effects of opioids on the immune …
chronic pain than the general population; however, the effects of opioids on the immune …
Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection
The twin pandemics of opioid abuse and HIV infection can have devastating effects on
physiological systems, including on the brain. Our previous work found that morphine …
physiological systems, including on the brain. Our previous work found that morphine …
Antiretroviral therapy restores the homeostatic state of microglia in SIV-infected rhesus macaques
Microglia and macrophages are essential for homeostatic maintenance and innate immune
response in the brain. They are the first line of defense against infections such as HIV/SIV in …
response in the brain. They are the first line of defense against infections such as HIV/SIV in …
Chronic Opioid Administration is Associated with Prevotella-dominated Dysbiosis in SIVmac251 Infected, cART-treated Macaques
People living with the human immunodeficiency virus (HIV) have an elevated risk of opioid
misuse due to both prescriptions for HIV-associated chronic pain and because injection drug …
misuse due to both prescriptions for HIV-associated chronic pain and because injection drug …
Systems biology analyses reveal enhanced chronic morphine distortion of gut-brain interrelationships in simian human immunodeficiency virus infected rhesus …
OA Olwenyi, SD Johnson, M Bidokhti… - Frontiers in …, 2022 - frontiersin.org
Background Commonly used opioids, such as morphine have been implicated in
augmented SIV/HIV persistence within the central nervous system (CNS). However, the …
augmented SIV/HIV persistence within the central nervous system (CNS). However, the …
[HTML][HTML] AKT signaling modulates latent viral reservoir viability in HIV-1-infected blood–brain barrier pericytes
Despite antiretroviral therapy (ART), chronic forms of HIV-associated neurocognitive
disorders (HAND) affect an estimated 50% of individuals living with HIV, greatly impacting …
disorders (HAND) affect an estimated 50% of individuals living with HIV, greatly impacting …
Deprenyl reduces inflammation during acute SIV infection
KM Emanuel, K Runner, ZD Brodnik, BM Morsey… - Iscience, 2022 - cell.com
In the era of antiretroviral therapy, inflammation is a central factor in numerous HIV-
associated comorbidities, such as cardiovascular disease, cognitive impairment, and …
associated comorbidities, such as cardiovascular disease, cognitive impairment, and …
The contributions of clinical pharmacology to HIV cure research
Combination antiretroviral therapy (ART) can suppress plasma HIV‐RNA to< 50 copies/mL,
decrease HIV transmission, reduce mortality, and improve quality of life for people living with …
decrease HIV transmission, reduce mortality, and improve quality of life for people living with …