Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …

Neuroinflammation was initially thought of as a consequence of neurodegenerative disease
pathology, but more recently it is becoming clear that it plays a significant role in the …

Recent studies have begun to reveal critical roles for the brain's professional phagocytes,
microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin …

As the resident macrophages of the brain and spinal cord, microglia are crucial for the
phagocytosis of infectious agents, apoptotic cells and synapses. During brain injury or …

Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …

Alzheimer's disease is a type of dementia characterized by problems with short-term
memory, cognition, and difficulties with activities of daily living. It is a progressive …

Alzheimer's disease (AD) is a progressive neurogenerative disorder manifested by gradual
memory loss and cognitive decline due to profound damage of cholinergic neurons. The …

Quantification of microglial activation through morphometric analysis has long been a staple
of the neuroimmunologist's toolkit. Microglial morphological phenomics can be conducted …

Alzheimer's Disease (AD) is the most common cause of dementia, having a remarkable
social and healthcare burden worldwide. Amyloid β (Aβ) and protein Tau aggregates are …

Microglia are the cells that comprise the innate immune system in the brain. First described
more than a century ago, these cells were initially assigned a secondary role in the central …