Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications

D Tsiapalis, L O'Driscoll - Cells, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) are being extensively investigated for their potential in
tissue engineering and regenerative medicine. However, recent evidence suggests that the …

[HTML][HTML] Extracellular vesicles as bioactive nanotherapeutics: an emerging paradigm for regenerative medicine

M Li, F Fang, M Sun, Y Zhang, M Hu, J Zhang - Theranostics, 2022 - ncbi.nlm.nih.gov
In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles
which are involved in various physiological and pathological processes including cell …

Differential therapeutic effect of extracellular vesicles derived by bone marrow and adipose mesenchymal stem cells on wound healing of diabetic ulcers and …

M Pomatto, C Gai, F Negro, M Cedrino… - International journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) derived from mesenchymal stem cells isolated from both bone
marrow (BMSCs) and adipose tissue (ADSCs) show potential therapeutic effects. These …

Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes

C Zheng, B Sui, X Zhang, J Hu, J Chen… - Journal of …, 2021 - Wiley Online Library
Apoptosis is a naturally occurring process generating plenty of apoptotic vesicles (apoVs),
but the feature, fate and function of apoVs remain largely unknown. Notably, as an …

Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

A Nagelkerke, M Ojansivu, L van der Koog… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting
as delivery vehicles for molecular messages. During the last decade, EVs have been …

Adipose‐derived mesenchymal stem cell‐derived exosomes biopotentiated extracellular matrix hydrogels accelerate diabetic wound healing and skin regeneration

Y Song, Y You, X Xu, J Lu, X Huang, J Zhang… - Advanced …, 2023 - Wiley Online Library
Wound healing is an urgent clinical challenge, particularly in the case of chronic wounds.
Traditional approaches to wound healing have limited therapeutic efficacy due to lengthy …

[HTML][HTML] Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy

TT Tang, B Wang, LL Lv, BC Liu - Theranostics, 2020 - ncbi.nlm.nih.gov
Dysregulated inflammation is a complicated pathological process involved in various
diseases, and the treatment of inflammation-linked disorders currently represents an …

Mesenchymal stem cell-derived extracellular vesicles: regenerative potential and challenges

S Fuloria, V Subramaniyan, R Dahiya, S Dahiya… - Biology, 2021 - mdpi.com
Simple Summary Mesenchymal stem cell extracellular vesicles (MSCEVs) obtained from
MSCs can have numerous therapeutic applications via regeneration of various body tissues …

[HTML][HTML] Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair

D Hao, L Lu, H Song, Y Duan, J Chen, R Carney… - Theranostics, 2022 - ncbi.nlm.nih.gov
Although stem cell-derived extracellular vesicles (EVs) have remarkable therapeutic
potential for various diseases, the therapeutic efficacy of EVs is limited due to their …

Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb …

X Zhang, Y Jiang, Q Huang, Z Wu, H Pu, Z Xu… - Stem Cell Research & …, 2021 - Springer
Background Diabetic limb ischemia is a clinical syndrome and refractory to therapy. Our
previous study demonstrated that adipose-derived stem cells (ADSCs) overexpressing …