[HTML][HTML] Glycosyltransferases in cancer: prognostic biomarkers of survival in patient cohorts and impact on malignancy in experimental models

M Pucci, M Duca, N Malagolini, F Dall'Olio - Cancers, 2022 - mdpi.com
Simple Summary Cancer-associated glycosylation changes are widely used as biomarkers
and strongly impact malignancy. However, the clinical significance of the deranged …

[HTML][HTML] HN1L/AP-2γ/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma

TT Zeng, TH Deng, Z Liu, JR Zhan, YZ Ma… - Cell Death & …, 2022 - nature.com
Hematological and neurological expressed 1 like (HN1L) is a newly identified oncogene in
lung cancer and hepatocellular carcinoma recently identified by our team, but its roles in the …

Curcumin inhibits the invasion and migration of pancreatic cancer cells by upregulating TFPI-2 to regulate ERK-and JNK-mediated epithelial–mesenchymal transition

LL Zhai, WB Li, LJ Chen, W Wang, TF Ju… - European Journal of …, 2024 - Springer
Purpose Pancreatic cancer (PC) is one of the most deadly human malignancies. Curcumin
is a natural polyphenolic compound with wide-ranging pharmacological effects. Growing …

[HTML][HTML] CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway

X Wang, Y Liu, Y Ding, G Feng - Scientific Reports, 2022 - nature.com
CAMSAP2 has been reported to act as an oncogene in hepatocellular carcinoma. However,
the expression CAMSAP2 and its potential roles in colorectal cancer remain unclear. In this …

A novel bioavailable curcumin-galactomannan complex modulates the genes responsible for the development of chronic diseases in mice: A RNA sequence analysis

K Banik, E Khatoon, M Hegde, KK Thakur, ER Puppala… - Life Sciences, 2021 - Elsevier
Background Chronic diseases or non-communicable diseases are a major burden
worldwide due to the lack of highly efficacious treatment modalities and the serious side …

[HTML][HTML] High-risk HPV16 E6 activates the cGMP/PKG pathway through glycosyltransferase ST6GAL1 in cervical cancer cells

J Wang, G Liu, M Liu, Q Cai, C Yao, H Chen… - Frontiers in …, 2021 - frontiersin.org
Alterations in glycosylation regulate fundamental molecular and cellular processes of
cancer, serving as important biomarkers and therapeutic targets. However, the potential …

[HTML][HTML] B4GALNT1 promotes hepatocellular carcinoma stemness and progression via integrin α2β1-mediated FAK and AKT activation

Y Tang, Z Xu, F Xu, J Ye, J Chen, J He, Y Chen, C Qi… - JHEP Reports, 2023 - Elsevier
Background & Aims β-1, 4-N-Acetyl-galactosaminyltransferase 1 (B4GALNT1) has been
reported to contribute to the development of human malignancies. However, its role in …

[HTML][HTML] Identification of a novel glycosyltransferase prognostic signature in hepatocellular carcinoma based on LASSO algorithm

Z Zhou, T Wang, Y Du, J Deng, G Gao, J Zhang - Frontiers in Genetics, 2022 - frontiersin.org
Although many prognostic models have been developed to help determine personalized
prognoses and treatments, the predictive efficiency of these prognostic models in …

[HTML][HTML] Androgen receptor variant 7 exacerbates hepatocarcinogenesis in a c-MYC-driven mouse HCC model

T Kido, YFC Lau - Oncogenesis, 2023 - nature.com
Androgen receptor variant 7 (AR-V7), an AR isoform with a truncated ligand-binding domain,
functions as a transcription factor in an androgen-independent manner. AR-V7 is expressed …

Cancer stem cell-mediated drug resistance: A comprehensive gene expression profile analysis in breast cancer

P Torabian, H Yousefi, A Fallah, Z Moradi… - … -Research and Practice, 2023 - Elsevier
Breast cancer is the most frequently diagnosed malignancy in women and a major public
health concern. In the current report, differential expression of the breast cancer resistance …