[HTML][HTML] 15 years of GWAS discovery: realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
[HTML][HTML] T cell responses to SARS-CoV-2
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …
[HTML][HTML] The human genetic epidemiology of COVID-19
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
[HTML][HTML] Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects
Multiple COVID-19 genome-wide association studies (GWASs) have identified reproducible
genetic associations indicating that there is a genetic component to susceptibility and …
genetic associations indicating that there is a genetic component to susceptibility and …
[HTML][HTML] Annotating and prioritizing human non-coding variants with RegulomeDB v. 2
Nearly 90% of the disease risk-associated variants identified by genome-wide association
studies are in non-coding regions of the genome. The annotations obtained by analyzing …
studies are in non-coding regions of the genome. The annotations obtained by analyzing …
[HTML][HTML] Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19
CI van der Made, MG Netea, FL van der Veerdonk… - Genome medicine, 2022 - Springer
Since the start of the coronavirus disease 2019 (COVID-19) pandemic, important insights
have been gained into virus biology and the host factors that modulate the human immune …
have been gained into virus biology and the host factors that modulate the human immune …
[HTML][HTML] COVID-19 annual update: a narrative review
M Biancolella, VL Colona, L Luzzatto, JL Watt… - Human genomics, 2023 - Springer
Three and a half years after the pandemic outbreak, now that WHO has formally declared
that the emergency is over, COVID-19 is still a significant global issue. Here, we focus on …
that the emergency is over, COVID-19 is still a significant global issue. Here, we focus on …
[HTML][HTML] Variant to function mapping at single-cell resolution through network propagation
Genome-wide association studies in combination with single-cell genomic atlases can
provide insights into the mechanisms of disease-causal genetic variation. However …
provide insights into the mechanisms of disease-causal genetic variation. However …
[HTML][HTML] ABO blood group antigens and differential glycan expression: perspective on the evolution of common human enzyme deficiencies
RP Jajosky, SC Wu, L Zheng, AN Jajosky, PG Jajosky… - Iscience, 2023 - cell.com
Enzymes catalyze biochemical reactions and play critical roles in human health and
disease. Enzyme variants and deficiencies can lead to variable expression of glycans, which …
disease. Enzyme variants and deficiencies can lead to variable expression of glycans, which …
[HTML][HTML] Genome-wide association studies of COVID-19: Connecting the dots
LC Ferreira, CEM Gomes, JF Rodrigues-Neto… - Infection, Genetics and …, 2022 - Elsevier
Genome-wide association studies (GWASs) are a research approach used to identify
genetic variants associated with common diseases, like COVID-19. The lead genetic …
genetic variants associated with common diseases, like COVID-19. The lead genetic …