CAR T cells: driving the road from the laboratory to the clinic

EJ Cheadle, H Gornall, V Baldan… - Immunological …, 2014 - Wiley Online Library
Blockbuster antibody therapies have catapulted immune‐based approaches to treat cancer
into the consciousness of mainstay clinical research. On the back of this, other emerging …

Strategies for enhancing and preserving anti-leukemia effects without aggravating graft-versus-host disease

YJ Chang, XY Zhao, XJ Huang - Frontiers in immunology, 2018 - frontiersin.org
Allogeneic stem cell transplantation (allo-SCT) is a curable method for the treatment of
hematological malignancies. In the past two decades, the establishment of haploidentical …

Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

AB van der Waart, NMP van de Weem… - Blood, The Journal …, 2014 - ashpublications.org
Effective T-cell therapy against cancer is dependent on the formation of long-lived, stem cell–
like T cells with the ability to self-renew and differentiate into potent effector cells. Here, we …

[HTML][HTML] HLA-haploidentical donor lymphocyte infusions for patients with relapsed hematologic malignancies after related HLA-haploidentical bone marrow …

AM Zeidan, PM Forde, H Symons, A Chen… - Biology of Blood and …, 2014 - Elsevier
Abstract Treatment of relapse after related HLA-haploidentical T cell–replete bone marrow
transplantation (haploBMT) with post-transplantation cyclophosphamide (PTCy) using …

[HTML][HTML] Immune reconstitution after haploidentical hematopoietic stem cell transplantation

YJ Chang, XY Zhao, XJ Huang - Biology of Blood and Marrow …, 2014 - Elsevier
Haploidentical hematopoietic stem cell transplantation (HSCT) offers the benefits of rapid
and nearly universal donor availability and has been accepted worldwide as an alternative …

Donor lymphocyte infusion after allogeneic stem cell transplantation

L Castagna, B Sarina, S Bramanti, P Perseghin… - … and Apheresis Science, 2016 - Elsevier
Allogeneic stem cell transplantation (allo-SCT) is considered the cornerstone in the
treatment of several malignant and not malignant hematological diseases. However, relapse …

[HTML][HTML] Donor lymphocyte infusions in AML and MDS: Enhancing the graft-versus-leukemia effect

G Orti, P Barba, L Fox, O Salamero, F Bosch… - Experimental …, 2017 - Elsevier
Highlights•Donor lymphocyte infusion (DLI) provides a way to enhance the graft-versus-
leukemia effect.•GvHD represents the main toxicity after DLI.•Pre-DLI low disease burden …

Donor-derived anti-CD19 CAR T cells compared with donor lymphocyte infusion for recurrent B-ALL after allogeneic hematopoietic stem cell transplantation

J Hua, J Zhang, X Zhang, X Wu, L Zhou… - Bone Marrow …, 2021 - nature.com
The efficacy and safety of donor-derived anti-CD19 CAR T cells vs DLI for the management
of relapsed B-cell acute lymphoblastic leukemia (B-ALL) after allo-hematopoietic stem cell …

[HTML][HTML] Phase II study of sequential infusion of donor lymphocyte infusion and cytokine-induced killer cells for patients relapsed after allogeneic hematopoietic stem …

M Introna, F Lussana, A Algarotti, E Gotti… - Biology of Blood and …, 2017 - Elsevier
Seventy-four patients who relapsed after allogeneic stem cell transplantation were enrolled
in a phase IIA study and treated with the sequential infusion of donor lymphocyte infusion …

T cells are required for orthodontic tooth movement

Y Yan, F Liu, X Kou, D Liu, R Yang… - Journal of dental …, 2015 - journals.sagepub.com
The immune system plays a pivotal role during bone remodeling process. Orthodontic tooth
movement (OTM) induces local inflammation in periodontium, but whether systemic immune …