New bioactive secondary metabolites from fungi: 2023

Y Shi, M Ji, J Dong, D Shi, Y Wang, L Liu, S Feng, L Liu - Mycology, 2024 - Taylor & Francis
Fungi have been identified as a prolific source of structurally unique secondary metabolites,
many of which display promising biological and pharmacological properties. This review …

The First Discovery of Marine Polyoxygenated Cembranolides as Potential Agents for the Treatment of Ulcerative Colitis

YY Cui, Y Jin, RN Sun, X Wang, CL Gao… - Journal of Medicinal …, 2024 - ACS Publications
Cembranolides are characteristic metabolites in marine soft corals, with complex structures
and widespread biological activities. However, seldom has an intensive pharmacological …

Structural clarification of mannoglucan GSBP-2 from Ganoderma sinense and its effects on triple-negative breast cancer migration and invasion

Y Xie, Y Su, Y Wang, D Zhang, Q Yu, C Yan - International Journal of …, 2024 - Elsevier
Ganoderma sinense, known as Lingzhi in China, is a medicinal fungus with anti-tumor
properties. Herein, crude polysaccharides (GSB) extracted from G. sinense fruiting bodies …

Discovery of Oxidized p-Terphenyls as Phosphodiesterase 4 Inhibitors from Marine-Derived Fungi

J Cai, Q Zhou, X Qi, F Zhang, J Yang… - Journal of Natural …, 2024 - ACS Publications
Four new p-terphenyl derivatives, talaroterphenyls A–D (1–4), together with three
biosynthetically related known ones (5–7), were obtained from the mangrove sediment …

Curdepsidone A Induces Intrinsic Apoptosis and Inhibits Protective Autophagy via the ROS/PI3K/AKT Signaling Pathway in HeLa Cells

S Xu, Z Li, X Xin, F An - Marine Drugs, 2024 - mdpi.com
Among female oncology patients, cervical cancer stands as the fourth most prevalent
malignancy, exerting significant impacts on their health. Over 600,000 women received the …

Zedoary turmeric oil injection ameliorates lung inflammation via platelet factor 4 and regulates gut microbiota disorder in respiratory syncytial virus-infected young …

YZ Wu, Q Zhang, H Li, CX Jiang, XK Li, HC Shang… - Chinese Medicine, 2024 - Springer
Background Respiratory syncytial virus (RSV)-induced lung inflammation is one of the main
causes of hospitalization and easily causes disruption of intestinal homeostasis in infants …

Octahydroindolizine Alkaloid Homocrepidine A from Dendrobium Crepidatum Attenuate P. acnes-Induced Inflammatory in Vitro and in Vivo

L Gong, J Xu, M Guo, J Zhao, X Xin, C Zhang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Dendrobium crepidatum Lindl. ex Paxton is a
perennial epiphyte of Dendrobium genus, distributed in southern China, and utilized as the …

Characteristic terpenylated coumarins from Ferula ferulaeoides as potential inhibitors on overactivation of microglia

Y Jia, W Dang, X Zhang, Y Mi, T Guo, D Mu, D Zhou… - Bioorganic …, 2024 - Elsevier
A total of 37 characteristic terpenylated coumarins (1–25), including 17 undescribed
compounds (1–5, 6a/6b, 7–10, 11a/11b–13a/13b), have been isolated from the root of …

Discovery of novel natural cardiomyocyte protectants from a toxigenic fungus Stachybotrys chartarum

S Lin, H Zeng, C Wang, Z Chai, X Zhang, B Yang… - Bioorganic …, 2024 - Elsevier
Abstract Stachybatranones A–F (1a/1b and 2–6) and three known analogues, namely
methylatranones A and B (7 and 8) and atranone B (9), were isolated and identified from a …

Biosynthesis of Natural and Unnatural Perylenequinones for Drug Development

Z Su, Y Zhang, Z Yuan, Y Rao - ChemMedChem, 2024 - Wiley Online Library
A wide range of perylenequinones (PQs) with diverse structures and versatile bioactivities
have long been isolated, positioning them as highly promising agents for photodynamic …