Simple Summary Pediatric sarcomas, including Ewing sarcoma and osteosarcoma, were
first to be treated with an anticancer vaccine 100 years ago. This review moves on from a …

Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors
mainly occurring in children, adolescents and young adults. Current standard therapy …

Simple Summary Soft tissue and bone sarcomas belong to a group of rare and malignant
tumors. The treatment of these tumors is very complex and depends on their specific …

Ewing sarcomas are aggressive pediatric tumors of bone and soft tissues driven by in frame
chromosomal translocations that yield fusion proteins guiding the oncogenic program …

Simple Summary Recent studies have shown the pro-tumoral role of tumor-associated
macrophages (TAMs) not only in major types of carcinomas but also in sarcomas. Several …

Simple Summary The systemic treatment of advanced sarcoma remains challenging.
Conventional chemotherapy and anti-angiogenic agents, even in the most responsive …

Tissue engineering is becoming increasingly successful in providing in vitro models of
human tissues that can be used for ex vivo recapitulation of functional tissues as well as …

Sarcomas comprise a collection of highly heterogeneous malignancies that can be grossly
grouped in the categories of sarcomas with simple or complex genomes. Since the outcome …

Simple Summary Tumor-associated macrophages (TAMs) are a class of immune cells
present in solid tumors and they are involved in cancer-related inflammation. However, to …

Metastasis is responsible for more than 90% of cancer deaths, but remains the least
understood stage of tumor progression. The tumor microenvironment contains multiple cells …