Human organoids recapitulate the cell type diversity and function of their primary organs
holding tremendous potentials for basic and translational research. Advances in single‐cell …

Background: Non-alcoholic fatty liver disease (NAFLD) is a liver disease associated with
obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and metabolic syndrome. The …

Sick, male, and older populations are more vulnerable to COVID-19. However, it remains
unclear whether a common mechanism exists across different demographic characteristics …

Mendelian randomization (MR) is an epidemiological method that uses genetic variants to
proxy an exposure predicting its causal association with an outcome. It occupies a valuable …

Genome-wide association studies (GWASs) have successfully identified thousands of
genetic variants that are reliably associated with human traits. Although GWASs are …

Despite two years of intense global research activity, host genetic factors that predispose to
a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise …

Background and Aims A recent study suggested that administration of ursodeoxycholic acid
(UDCA) at dosages usually employed clinically may reduce rates of severe acute respiratory …

Background Alzheimer's disease (AD) is the leading cause of dementia. Currently, there are
no effective disease-modifying treatments for AD. Mendelian randomisation (MR) has been …

Background Drug repurposing provides a cost-effective approach to address the need for
breast cancer prevention and therapeutics. We aimed to identify actionable druggable …

Several genetic associations have been identified in individuals with severe COVID-19 and
MIS-C via various genetic approaches. Broadly speaking, COVID-19 genetic associations …