Host genetics of pediatric SARS-CoV-2 COVID-19 and multisystem inflammatory syndrome in children

GS Schulert, SA Blum, RQ Cron - Current opinion in pediatrics, 2021 - journals.lww.com
Several genetic associations have been identified in individuals with severe COVID-19 and
MIS-C via various genetic approaches. Broadly speaking, COVID-19 genetic associations …

SARS-CoV-2 antibody isotypes in systemic lupus erythematosus patients prior to vaccination: associations with disease activity, antinuclear antibodies, and …

J Sjöwall, M Azharuddin, M Frodlund, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Objectives Impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic on individuals with arthritis has been highlighted whereas data on other …

Potential of microneedle systems for COVID-19 vaccination: current trends and challenges

J Hassan, C Haigh, T Ahmed, MJ Uddin, DB Das - Pharmaceutics, 2022 - mdpi.com
To prevent the coronavirus disease 2019 (COVID-19) pandemic and aid restoration to
prepandemic normality, global mass vaccination is urgently needed. Inducing herd immunity …

Mendelian randomization using the druggable genome reveals genetically supported drug targets for psychiatric disorders

X Li, A Shen, Y Zhao, J Xia - Schizophrenia bulletin, 2023 - academic.oup.com
Background and hypothesis Psychiatric disorders impose a huge health and economic
burden on modern society. However, there is currently no proven completely effective …

[HTML][HTML] Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges

AP Yusuf, J Zhang, J Li, A Muhammad, MB Abubakar - Phytomedicine plus, 2022 - Elsevier
Background The presence of diabetes mellitus (DM) among COVID-19 patients is
associated with increased hospitalization, morbidity, and mortality. Evidence has shown that …

Harnessing the power of electronic health records and genomics for drug discovery

K Krebs, L Milani - Annual Review of Pharmacology and …, 2023 - annualreviews.org
A long-standing recognition that information from human genetics studies has the potential
to accelerate drug discovery has led to decades of research on how to leverage genetic and …

Polymorphisms and mutations of ACE2 and TMPRSS2 genes are associated with COVID-19: a systematic review

J Li, Y Wang, Y Liu, Z Zhang, Y Zhai, Y Dai… - European Journal of …, 2022 - Springer
Objective To determine the effect of polymorphisms and mutations in angiotensin-converting
enzyme 2 (ACE2) and Type 2 transmembrane serine proteases (TMPRSS2) genes on …

[HTML][HTML] IUPHAR review–Data-driven computational drug repurposing approaches for opioid use disorder

Z Gao, P Ding, R Xu - Pharmacological Research, 2024 - Elsevier
Abstract Opioid Use Disorder (OUD) is a chronic and relapsing condition characterized by
the misuse of opioid drugs, causing significant morbidity and mortality in the United States …

Genome-wide association analyses of common infections in a large practice-based biobank

L Jiang, VE Kerchberger, C Shaffer, AL Dickson… - BMC genomics, 2022 - Springer
Introduction Infectious diseases are common causes of morbidity and mortality worldwide.
Susceptibility to infection is highly heritable; however, little has been done to identify the …

Vaccination history, body mass index, age, and baseline gene expression predict influenza vaccination outcomes

CV Forst, M Chung, M Hockman, L Lashua, E Adney… - Viruses, 2022 - mdpi.com
Seasonal influenza is a primary public health burden in the USA and globally. Annual
vaccination programs are designed on the basis of circulating influenza viral strains …