With the nucleus as an exception, mitochondria are the only animal cell organelles
containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte …

During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

Melatonin, mostly released by the pineal gland, is a circadian rhythm-regulated and
multifunctional hormone. Great advances in melatonin research have been made, including …

The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …

Reduced quality in oocytes from women of advanced maternal age (AMA) is associated with
dysfunctional mitochondria. The objective of this study was to investigate the mechanisms …

Abstract Sirtuin-3 (SIRT3), the main deacetylase in the mitochondria, maintains cellular
energy metabolism and redox balance by deacetylating mitochondrial proteins in a NAD+ …

Contemporary scientists need no “p value” and “relative risk” statistics to be exquisitely
aware of the increasing prevalence of obesity and complications posed by obesity. It is now …

Basic scientific research on human reproduction and oxidative damage has been
extensively performed; however, a more clinical view is still lacking. As a result, exhaustive …

The female reproductive system is quite sensitive to regulation, and external environmental
stimuli may cause oxidative stress which in turn may lead to accelerated aging and …

Decreased oocyte quality and compromised embryo development are particularly prevalent
in older females, but the aging-related cellular processes and effective ameliorative …