All cells undergo rapid remodeling of their actin networks to regulate such critical processes
as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. These events are driven …

The establishment of cell polarity is critical for the development of many organisms and for
the function of many cell types. A large number of studies of diverse organisms from yeast to …

The mechanism underlying cytokinesis, the final step in cell division, remains one of the
major unsolved questions in basic cell biology. Thanks to advances in functional genomics …

The ability to evolve is a fundamental feature of biological systems, but the mechanisms
underlying this capacity and the evolutionary dynamics of conserved core processes remain …

Cellular myosin II is the principal motor responsible for cytokinesis. In higher eukaryotes,
phosphorylation of the regulatory light chain (MLC) of myosin II is a primary means of …

Cells precisely control the formation of dynamic actin cytoskeleton networks to coordinate
fundamental processes, including motility, division, endocytosis and polarization. To support …

Septins are conserved GTP-binding proteins that assemble into hetero-oligomeric
complexes and higher-order structures such as filaments, rings, hourglasses or gauzes …

We observed live fission yeast expressing pairs of functional fluorescent fusion proteins to
test the popular model that the cytokinetic contractile ring assembles from a single myosin II …

Cell division facilitated by a contractile ring is an almost universal feature across all
branches of cellular life, with the notable exception of higher plants. In all organisms that use …

The abscission checkpoint contributes to the fidelity of chromosome segregation by delaying
completion of cytokinesis (abscission) when there is chromatin lagging in the intercellular …