Both tumor cell proliferation and metastasis are dependent on myosin II. Because UNC-45 is
required to chaperone the assembly of a functional myosin II motor, we examined the …

Background Cytokinesis in many eukaryotes involves the function of an actomyosin-based
contractile ring. In fission yeast, actomyosin ring maturation and stability require a conserved …

Correct positioning of the cell-division plane is crucial for cell function in all organisms. The
fission yeast Schizosaccharomyces pombe divides by utilizing an actomyosin-based …

The conserved NDR-kinase Dbf2 plays a critical role in cytokinesis in budding yeast. Among
its cytokinesis-related substrates is the F-BAR protein Hof1. Hof1 colocalizes at the cell …

The ability of fungi to generate polarized cells with a variety of shapes likely reflects precise
temporal and spatial control over the formation of polarity axes. The bud site selection …

The mRNA-binding protein Ssd1 is a substrate for the Saccharomyces cerevisiae
LATS/NDR orthologue Cbk1, which controls polarized growth, cell separation, and cell …

The position of the division plane affects cell shape and size, as well as tissue organization.
Cells of the fission yeast Schizosaccharomyces pombe have a centrally placed nucleus and …

Cell division in the fission yeast Schizosaccharomyces pombe requires the formation and
constriction of an actomyosin ring at the division site. The actomyosin ring is assembled in …

Comparative genomics reveals an unexpected diversity in the molecular mechanisms
underlying conserved cellular functions, such as DNA replication and cytokinesis. However …

Neurodegenerative disorders have a profound effect on the quality of life of patients and
their environment. However, the development of adequate therapies requires accurate …