An insight into cellular and molecular mechanisms underlying the pathogenesis of neurodegeneration in Alzheimer's disease
Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …
[HTML][HTML] Genomics and functional genomics of Alzheimer's disease
MI Kamboh - Neurotherapeutics, 2023 - Elsevier
Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease. Due to
its long clinical course and lack of an effective treatment, AD has become a major public …
its long clinical course and lack of an effective treatment, AD has become a major public …
[HTML][HTML] Translational approaches to understanding resilience to Alzheimer's disease
Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease
JM Eissman, L Dumitrescu, ER Mahoney, AN Smith… - Brain, 2022 - academic.oup.com
Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the
presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are …
presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are …
Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease
Neurogenesis, crucial for brain resilience, is reduced in Alzheimer's disease (AD) that
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …
Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature
E Berson, A Sreenivas, T Phongpreecha… - Nature …, 2023 - nature.com
Abstract Assay for Transposase Accessible Chromatin by sequencing (ATAC-seq)
accurately depicts the chromatin regulatory state and altered mechanisms guiding gene …
accurately depicts the chromatin regulatory state and altered mechanisms guiding gene …
Cognitive domain harmonization and cocalibration in studies of older adults.
Objective: Studies use different instruments to measure cognitirating cognitive tests permit
direct comparisons of individuals across studies and pooling data for joint analyses. Method …
direct comparisons of individuals across studies and pooling data for joint analyses. Method …
Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease
Amyloid PET imaging has been crucial for detecting the accumulation of amyloid beta (Aβ)
deposits in the brain and to study Alzheimer's disease (AD). We performed a genome-wide …
deposits in the brain and to study Alzheimer's disease (AD). We performed a genome-wide …
KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease
Abstract Klotho-VS heterozygosity (KL-VShet) is associated with reduced risk of Alzheimer's
disease (AD). However, whether KL-VShet is associated with lower levels of pathologic tau …
disease (AD). However, whether KL-VShet is associated with lower levels of pathologic tau …
[HTML][HTML] Remembering your A, B, C's: Alzheimer's disease and ABCA1
CT Lewandowski, MS Laham, GRJ Thatcher - Acta Pharmaceutica Sinica B, 2022 - Elsevier
The function of ATP binding cassette protein A1 (ABCA1) is central to cholesterol
mobilization. Reduced ABCA1 expression or activity is implicated in Alzheimer's disease …
mobilization. Reduced ABCA1 expression or activity is implicated in Alzheimer's disease …