Objective The aim of the current study is to understand why some individuals avoid
developing Parkinson disease (PD) despite being at relatively high genetic risk, using the …

Resilience is broadly defined as the ability to maintain or regain functioning in the face of
adversity and is influenced by both environmental and genetic factors. The identification of …

Recent clinical studies have revealed that the serum levels of toxic hydrophobic bile acids
(deoxy cholic acid, lithocholic acid [LCA], and glycoursodeoxycholic acid) are significantly …

Emerging evidence indicates an important role for neuroinflammation in depression. Brief
maternal separation promotes resilience to depression in offspring, but relatively little is …

Across neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's
disease (AD), a disparity between the clinical expression and the extent of …

Background More than 75 common variant loci account for only a portion of the heritability
for Alzheimer's disease (AD). A more complete understanding of the genetic basis of AD can …

Alzheimer disease is one of the most challenging demons in our society due to its very high
prevalence and its clinical manifestations which cause deterioration of cognition …

Abstract Alzheimer's disease (AD)-related neurofibrillary tangles (NFT), argyrophilic grain
disease (AGD), aging-related tau astrogliopathy (ARTAG), limbic predominant TDP-43 …

Asymmetric distribution of phospholipids in eukaryotic membranes is essential for cell
integrity, signaling pathways, and vesicular trafficking. P4-ATPases, also known as …

Alzheimer's disease (AD) is characterized by the abnormal deposition of amyloid-β (Aβ)
plaques and tau tangles in the brain and accompanied with cognitive impairment. However …