Aprominent pathology textbook used in the United States includes an image illustrating the
renal histopathology caused by malignant hypertension. The legend describes striking …

Inhibitors of tumour necrosis factor (TNF) are among the most successful protein-based
drugs (biologics) and have proven to be clinically efficacious at reducing inflammation …

Although considerable progress has been made in understanding how tumors evade
immune surveillance, measures to counter the same have not kept pace with the advances …

1BB (CD137), a member of the TNF receptor superfamily, is an activation-induced T-cell
costimulatory molecule. Signaling via 4-1BB upregulates survival genes, enhances cell …

Although the earliest—rudimentary—attempts at exploiting the immune system for cancer
therapy can be traced back to the late 18th Century, it was not until the past decade that …

Proteins in the TNF/TNFR superfamily are recognized as major regulators of the activity of
conventional CD4 and CD8 T cells, and also of regulatory T cells (Treg). Stimulatory …

The tumor necrosis factor (TNF) ligand and cognate TNF receptor superfamilies constitute
an important regulatory axis that is pivotal for immune homeostasis and correct execution of …

Cysteine-rich secretory proteins (CRISPs) have been identified as a toxin family in most
animal venoms with biological functions mainly associated with the ion channel activity of …

Tumor necrosis factor, a regulatory cytokine, is extremely important signaling protein in the
immune system. Among TNF family, TNF-alpha, TNF-beta are most the significant family …

Chronic bacterial infections are caused by pathogens that persist within their hosts and
avoid clearance by the immune system. Treatment and/or detection of such pathogens is …