Hypothermia and kidney: a focus on ischaemia–reperfusion injury

S De Rosa, M Antonelli, C Ronco - Nephrology Dialysis …, 2017 - academic.oup.com
Cellular damage after reperfusion of ischaemic tissue is defined as ischaemia–reperfusion
injury (IRI). Hypothermia is able to decrease oxygen consumption, preventing a rapid loss of …

Development of pancreatic machine perfusion: translational steps from porcine to human models

K Hamaoui, S Gowers, B Sandhu, N Vallant… - Journal of Surgical …, 2018 - Elsevier
Background Hypothermic machine perfusion (HMP) is increasingly being used for extended
criteria kidney grafts. Pancreatic HMP is challenging because physiologically the pancreas …

Subnormothermic Perfusion with H2S Donor AP39 Improves DCD Porcine Renal Graft Outcomes in an Ex Vivo Model of Kidney Preservation and Reperfusion

S Juriasingani, A Ruthirakanthan, M Richard-Mohamed… - Biomolecules, 2021 - mdpi.com
Cold preservation is the standard of care for renal grafts. However, research on alternatives
like perfusion at higher temperatures and supplementing preservation solutions with …

[HTML][HTML] Current protective strategies in liver surgery

KS Gurusamy, HD Gonzalez… - World journal of …, 2010 - ncbi.nlm.nih.gov
During liver resection surgery for cancer or liver transplantation, the liver is subject to
ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow), which …

Hypothermic reconditioning in organ transplantation

T Minor, A Paul - Current opinion in organ transplantation, 2013 - journals.lww.com
Vascular and parenchymal tissue homeostasis can be restored to a notable extent in cold-
preserved organ grafts by hypothermic reconditioning: a short period of preimplantation …

Xeroprotectants for the stabilization of biomaterials

I Julca, M Alaminos, J González-López… - Biotechnology …, 2012 - Elsevier
With the advancement of science and technology, it is crucial to have effective preservation
methods for the stable long-term storage of biological material (biomaterials). As an …

Metabolic differences between cold stored and machine perfused porcine kidneys: A 1H NMR based study

J Nath, TB Smith, K Patel, SR Ebbs, A Hollis… - Cryobiology, 2017 - Elsevier
Hypothermic machine perfusion (HMP) and static cold storage (SCS) are the two methods
used to preserve deceased donor kidneys prior to transplant. This study seeks to …

One or 4 h of “in‐house” reconditioning by machine perfusion after cold storage improve reperfusion parameters in porcine kidneys

A Gallinat, P Efferz, A Paul, T Minor - Transplant International, 2014 - Wiley Online Library
In‐house machine perfusion after cold storage (hypothermic reconditioning) has been
proposed as convenient tool to improve kidney graft function. This study investigated the role …

Role of oxygenation in hypothermic machine perfusion of kidneys from heart beating donors

A Gallinat, A Paul, P Efferz, B Lüer, S Swoboda… - …, 2012 - journals.lww.com
Dynamic preservation of organ grafts by hypothermic machine perfusion (HMP) has
regained broader interest to provide better outcome after transplantation. One pivotal aspect …

Cold storage or normothermic perfusion for liver transplantation: probable application and indications

CDL Ceresa, D Nasralla, S Knight… - Current opinion in organ …, 2017 - journals.lww.com
NMP is an exciting new technological advancement in liver preservation, which is likely to
have a positive impact in liver transplantation. However, randomized controlled trials are …