Colorectal cancer (CRC) is one of the most frequent tumor entities worldwide with only
limited therapeutic options. CRC is not only a genetic disease with several mutations in …

Dendritic cells (DCs) play a key role to modulate anti-cancer immunity in the tumor
microenvironment (TME). They link innate to adaptive immunity by processing and …

RAS genes are the most frequently mutated oncogenes in cancer. These mutations occur in
roughly half of the patients with colorectal cancer (CRC). RAS mutant tumors are resistant to …

Disulfidptosis is a newly-identified non-programmed cell death mode with tight associations
with glucose metabolism. Elevated glycolysis is an important metabolic feature of tumor …

Colorectal cancer (CRC) remains one of the most aggressive and lethal cancers, with
metastasis accounting for most deaths. As such, there is an unmet need for improved …

Metastasis is the leading cause of cancer-related death. Despite extensive treatment, the
prognosis for patients with metastatic cancer remains poor. In addition to conventional …

As one of the main threats to human life (the fourth most dangerous and prevalent cancer),
colorectal cancer affects many people yearly, decreases patients' quality of life, and causes …

The gut epithelium not only provides a physical barrier to separate a noxious outside from a
sterile inside but also allows for highly regulated interactions between bacteria and their …

Based on amino acid metabolism-related genes (AAMRGs), this study aimed at screening
out key prognosis-related genes and finding the underlying correlation between the amino …

The tumor microenvironment (TME) is implicated in tumorigenesis, chemoresistance,
immunotherapy failure and tumor recurrence. Multiple immunosuppressive cells and soluble …