Diseases caused by mutations in ORAI1 and STIM1
Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
Molecular mechanisms of treg-mediated T cell suppression
A Schmidt, N Oberle, PH Krammer - Frontiers in immunology, 2012 - frontiersin.org
CD4+ CD25highFoxp3+ regulatory T cells (Tregs) can suppress other immune cells and,
thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs avert …
thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs avert …
Peripheral thermosensation in mammals
Our ability to perceive temperature is crucial: it enables us to swiftly react to noxiously cold or
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …
STIM proteins: dynamic calcium signal transducers
Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
Endoplasmic reticulum–plasma membrane contact sites
Y Saheki, P De Camilli - Annual review of biochemistry, 2017 - annualreviews.org
The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms
direct physical contacts with all other classes of membranous organelles, including the …
direct physical contacts with all other classes of membranous organelles, including the …
[HTML][HTML] Axonal endoplasmic reticulum Ca2+ content controls release probability in CNS nerve terminals
Although the endoplasmic reticulum (ER) extends throughout axons and axonal ER
dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is …
dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is …
Ion channels and transporters in lymphocyte function and immunity
S Feske, EY Skolnik, M Prakriya - Nature Reviews Immunology, 2012 - nature.com
Lymphocyte function is regulated by a network of ion channels and transporters in the
plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations …
plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations …
Calcium signaling and transcriptional regulation in cardiomyocytes
M Dewenter, A von der Lieth, HA Katus… - Circulation …, 2017 - Am Heart Assoc
Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …
Endoplasmic reticulum structure and interconnections with other organelles
AR English, GK Voeltz - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
The endoplasmic reticulum (ER) is a large, continuous membrane-bound organelle
comprised of functionally and structurally distinct domains including the nuclear envelope …
comprised of functionally and structurally distinct domains including the nuclear envelope …
Protein folding and quality control in the ER
K Araki, K Nagata - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
The endoplasmic reticulum (ER) uses an elaborate surveillance system called the ER
quality control (ERQC) system. The ERQC facilitates folding and modification of secretory …
quality control (ERQC) system. The ERQC facilitates folding and modification of secretory …