Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …

The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …

Amorphous–Amorphous phase separation (AAPS) is an important phenomenon that can
impede the performance of amorphous solid dispersions (ASDs). The purpose of this study …

Among many methods to mitigate the solubility limitations of drug compounds, amorphous
solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …

Novel polymeric carriers for amorphous solid dispersions (ASDs) are highly demanded in
pharmaceutical industry to improve the bioavailability of poorly-soluble drug candidates …

A pair of popular thermodynamic models for pharmaceutical applications, namely, the
perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state and the …

The bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be
improved via the formulation of an amorphous solid dispersion (ASD), where the API is …

Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs),
notable for its ability to enable the production of ASDs containing pharmaceuticals with …

In amorphous solid dispersions (ASDs), an active pharmaceutical ingredient (API) is
dissolved on a molecular level in a polymeric matrix. The API is expected to be released …

During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …