Background: Preparation of lipophilic compounds into solid dispersion formulations (SDs)
has been credited with increasing their dissolution rate. Understanding the role of the …

The number of drug molecules that show poor aqueous solubility and low dissolution rate
has significantly increased during the past two decades, resulting in low oral bioavailability …

Predictive thermodynamic modeling tools play an important role in the design of
pharmaceutical processes by focusing experimental efforts on promising areas and …

In this work we present a systematic computer-aided design methodology for identifying
optimal drug-polymer-water formulations with desired physical and chemical properties that …

A drawback of the current drug selection procedures is their high output of drug candidates
with unfavorable physicochemical properties12. More specifically, ca. 70% of new drug …

Uno de los problemas a los que se enfrenta el sector farmacéutico en la actualidad es que
en torno al 40% de los nuevos compuestos químicos potencialmente activos son poco …

A structured development approach is presented to guide the development of stable and
commercially viable polymer-based amorphous formulations. The proposed approach …