Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …

The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …

Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …

A pair of popular thermodynamic models for pharmaceutical applications, namely, the
perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state and the …

The bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be
improved via the formulation of an amorphous solid dispersion (ASD), where the API is …

Among many methods to mitigate the solubility limitations of drug compounds, amorphous
solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …

Novel polymeric carriers for amorphous solid dispersions (ASDs) are highly demanded in
pharmaceutical industry to improve the bioavailability of poorly-soluble drug candidates …

In amorphous solid dispersions (ASDs), an active pharmaceutical ingredient (API) is
dissolved on a molecular level in a polymeric matrix. The API is expected to be released …

Ternary mixtures of a semicrystalline (SC) polymer with a solvent and a nonsolvent are
widely used primarily for preparation of membranes by nonsolvent induced phase …

Amorphous–Amorphous phase separation (AAPS) is an important phenomenon that can
impede the performance of amorphous solid dispersions (ASDs). The purpose of this study …