The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven
synovitis exacerbates the pathological process. However, precise therapies for M1 …

Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration,
intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a noneuphoria …

A complex network of many interacting mechanisms orchestrates immune and inflammatory
responses. Among these, the cation channels of the transient receptor potential (TRP) family …

With osteoarthritis being the most common degenerative disease in pet animals, a very
broad panel of natural health products is available on the market for its management. The …

Chronic pain is a major comorbidity of chronic inflammatory diseases. Here, we report that
the cytokine IL-1β, which is abundantly produced during multiple sclerosis (MS), arthritis …

Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a
complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve …

Crystal structures activate innate immune cells, especially macrophages and initiate
inflammatory responses. We aimed to understand the role of the mechanosensitive TRPV4 …

Transient receptor potential vanilloid 1 (TRPV1) is an ion channel expressed on sensory
neurons triggering an influx of cations. TRPV1 receptors function as homotetramers …