The tumor microenvironment has been largely studied as a dynamic system orchestrated by
inflammatory cells, including cancer cells, stroma as well as the extracellular matrix. It is …

Hepatocellular carcinoma (HCC) is the most common form of liver cancer throughout the
world. The microenvironment of the HCC is composed of non-tumor cells and their stroma …

Immunosuppression mediated by regulatory T cells (Tregs) is a key facilitator of tumor
immune evasion, but the source of these Tregs and their contribution to human cancer …

Immunosuppressants are powerful drugs, capable of triggering severe adverse effects.
Hence, there is tremendous interest in replacing them with less‐toxic agents. Adoptive …

Chronic hepatitis B (CHB) virus hepatitis B virus (HBV) infection is the key cause of
hepatocellular carcinoma (HCC) in Asians. Recent studies have shown that levels of CD4+ …

The role of Foxp3-positive regulatory T cells (Foxp3+ Tregs) in suppression of antitumoral
immune response is well documented in patients with cancer. However, it is not known …

The immunosuppressive strategies devised by neuroblastoma (NB), the most common solid
extracranial childhood cancer, are poorly understood. Here, we identified an …

We have previously shown a decreased frequency and function of Tregs in women suffering
from recurrent spontaneous abortions (RSA). In the current study, we first investigated the …

Sorafenib was the only small-molecule drug approved by FDA for treatment of the advanced
hepatocellular carcinoma (HCC). Recent study indicated that YM155 was a promising agent …

The liver is an immunologically unique organ, consisting of resident hematopoietic and
parenchymal cells which often contribute to a relatively tolerant microenvironment. It is also …