The aquaporins (AQPs) are integral membrane proteins whose main function is to transport
water across cell membranes in response to osmotic gradients. At the ocular surface, AQP1 …

Background All thirteen known mammalian aquaporins have been detected in the eye.
Moreover, aquaporins have been identified as playing essential roles in ocular functions …

Müller glial cells ensheath all retinal neurons in vertebrate retinae. There are a multitude of
functional interactions between neurons and Müller cells, including delivery of the light …

Many diverse retinal disorders are characterized by retinal edema; yet, little experimental
attention has been given to understanding the fundamental mechanisms underlying and …

Evidence is mounting that not only microangiopathy, but also neurodegenerative events
occur in the retinas of humans and rodents with early diabetes. Diverse pathologies are …

Although the functionality of the lens water channels aquaporin 1 (AQP1; epithelium) and
AQP0 (fiber cells) is well established, less is known about the role of AQP5 in the lens. Since …

The glial water channel aquaporin-4 (AQP4) is implicated in the control of ion and
osmohomeostasis in the sensory retina. Using retinal slices from AQP4-deficient and wild …

Abstract Aquaporin 0 (AQP0) is a transmembrane channel that constitutes∼ 45% of the total
membrane protein of the fiber cells in mammalian lens. It is critical for lens transparency and …

Purpose/Aim: The development of retinal edema is the main reason of impaired vision in
non-proliferative diabetic retinopathy. Water transport through aquaporins (AQPs) has been …

Purpose.: To investigate the effect of chronically elevated intraocular pressure (IOP) on the
expression of water channel aquaporins (AQPs) 1, 4, and 9 in the optic nerve and retina in …