Phase separation provides a mechanism to drive phenotype switching
L Hong, Z Zhang, Z Wang, X Yu, J Zhang - Physical Review E, 2024 - APS
Phenotypic switching plays a crucial role in cell fate determination across various
organisms. Recent experimental findings highlight the significance of protein …
organisms. Recent experimental findings highlight the significance of protein …
Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage
Cells must adopt flexible regulatory strategies to make decisions regarding their fate,
including differentiation, apoptosis, or survival in the face of various external stimuli. One key …
including differentiation, apoptosis, or survival in the face of various external stimuli. One key …
Neuronal phenotype defined by transcriptome-wide bursting kinetics in pyramidal and fast-spiking cells
Single-cell sequencing revealed the transcriptional heterogeneity of neurons and introduced
transcriptome-defined neuron types and subtypes. Temporal recordings of gene …
transcriptome-defined neuron types and subtypes. Temporal recordings of gene …