Schizophrenia is a disease of abnormal brain development. Considerable evidence now
indicates that environmental factors have a causative role in schizophrenia. Elevated …

Background Whether schizophrenia and bipolar disorder are the clinical outcomes of
discrete or shared causative processes is much debated in psychiatry. We aimed to assess …

MicroRNAs (miRNAs) are short RNA molecules which bind to target mRNAs, resulting in
translational repression and gene silencing and are found in all eukaryotic cells …

Empirical studies suggest that psychiatric disorders result from a complex interplay between
genetic and environmental factors. Most evidence for such gene-environment interaction …

The NMDA-R hypofunction model of schizophrenia started with the clinical observation of
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …

In the present article the putative role of environmental factors in schizophrenia is reviewed
and synthesized. Accumulating evidence from recent studies suggests that environmental …

Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …

Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular
genetic research has produced novel findings, infusing optimism about discovering the …

Schizophrenia is a complex disorder caused by both genetic and environmental factors.
Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the …

Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of
patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal …