Hypofunction of N-methyl-d-aspartic acid-type glutamate receptors (NMDAR) induced by the
systemic administration of NMDAR antagonists is well known to cause schizophrenia-like …

Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning.
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …

Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …

Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive
deficits and apathy, with a heritability estimated at 73–90%(ref.). Inheritance patterns are …

The kynurenine pathway of tryptophan degradation generates several neuroactive
compounds. Of those, kynurenic acid is an N-methyl-d-aspartate (NMDA) and alpha7 …

Although we have studied schizophrenia as a major disease entity over the past century, its
causes and pathogenesis remain obscure. In this article, we critically review genetic and …

Abstract The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis)
Consortium was set up to analyze brain measures and genotypes from multiple sites across …

Recent research on lone-actor terrorism has found a high prevalence of mental health
disorders among these offenders. This research note addresses two shortcomings in these …

In an effort to pinpoint potential genetic risk factors for schizophrenia, research groups
worldwide have published over 1,000 genetic association studies with largely inconsistent …

Genes are major contributors to many psychiatric diseases, but their mechanisms of action
have long seemed elusive. The intermediate phenotype concept represents a strategy for …