The pathobiological basis of depression in Parkinson disease: challenges and outlooks

KA Jellinger - Journal of neural transmission, 2022 - Springer
Depression, with an estimated prevalence of about 40% is a most common neuropsychiatric
disorder in Parkinson disease (PD), with a negative impact on quality of life, cognitive …

The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder

KA Jellinger - Journal of Neural Transmission, 2023 - Springer
Depression is frequent in older individuals and is often associated with cognitive impairment
and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative …

Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort

RS Nelson, EL Abner, GA Jicha, FA Schmitt… - Acta Neuropathologica …, 2023 - Springer
In addition to the memory disorders and global cognitive impairment that accompany
neurodegenerative diseases, behavioral and psychological symptoms of dementia (BPSD) …

Depression pathophysiology: astrocyte mitochondrial melatonergic pathway as crucial hub

G Anderson - International Journal of Molecular Sciences, 2022 - mdpi.com
Major depressive disorder (MDD) is widely accepted as having a heterogenous
pathophysiology involving a complex mixture of systemic and CNS processes. A …

Sleep matters: Neurodegeneration spectrum heterogeneity, combustion and friction ultrafine particles, industrial nanoparticle pollution, and sleep disorders—Denial is …

L Calderón-Garcidueñas, R Torres-Jardón… - Frontiers in …, 2023 - frontiersin.org
Sustained exposures to ubiquitous outdoor/indoor fine particulate matter (PM2. 5), including
combustion and friction ultrafine PM (UFPM) and industrial nanoparticles (NPs) starting in …

The clinical phenotype of psychiatric-onset prodromal dementia with Lewy bodies: a scoping review

CW Gunawardana, E Matar, SJG Lewis - Journal of Neurology, 2024 - Springer
Background Recent consensus research criteria have identified a 'psychiatric onset'form of
prodromal dementia with Lewy bodies (DLB) characterised by prominent late-onset …

The enigma of vascular depression in old age: a critical update

KA Jellinger - Journal of Neural Transmission, 2022 - Springer
Depression is common in older individuals and is associated with high disability and
increased mortality, yet the factors predicting late-life depression (LLD) are poorly …

Prevalence and incidence of depressive symptoms and diagnosis of depression as associated with elevated amyloid among Medicare beneficiaries with cognitive …

E Bélanger, E Jutkowitz, P Shewmaker… - Journal of Affective …, 2023 - Elsevier
Background Depression and cognitive impairment commonly co-occur, and it has been
hypothesized that the two share pathological processes. Our objective for this study was to …

Distinguishing features of depression in dementia from primary psychiatric disease

DW Fisher, JT Dunn, H Dong - Discover Mental Health, 2024 - Springer
Depression is a common and devastating neuropsychiatric symptom in the elderly and in
patients with dementia. In particular, nearly 80% of patients with Alzheimer's Disease …

Dopaminergic Changes in the Subgenual Cingulate Cortex in Dementia with Lewy Bodies Associates with Presence of Depression

L Gliaudelyte, SP Rushton, R Berlinguer-Palmini… - bioRxiv, 2024 - biorxiv.org
In addition to the core clinical features of fluctuating cognition, visual hallucinations, and
parkinsonism, individuals with dementia with Lewy bodies (DLB) frequently experience …