The temporal and tissue-specific actions of estrogen are mediated by estrogen receptors α
and β. The ERs are steroid hormone receptors that modulate the transcription of target …

The essential role estrogen plays in reproductive endocrinology has been deciphered
during the 20th century. Estrogen is also important for supporting physiologic homeostasis in …

Background Although the Women's Health Initiative (WHI) trial of estrogen plus progestin in
postmenopausal women identified more overall health risks than benefits among women in …

Oestrogen Receptor β (ERβ) may protect against prostate and mammary cell proliferation
and malignant transformation. Epidemiological studies indicate that oestrogens may reduce …

We observed previously that estrogen treatment increased the transcript levels of several
mitochondrial DNA (mtDNA)-encoded genes for mitochondrial respiratory chain (MRC) …

Estrogen receptor β (ERβ) is the predominant ER in the colorectal epithelium. Compared
with normal colon tissue, ERβ expression is reduced in colorectal cancer. Our hypothesis is …

The discovery of the second estrogen receptor (ER) in 1995 surprised many
endocrinologists and resulted in some scepticism regarding its physiological importance …

BACKGROUND Estrogen receptors (ERs) are known to mediate important physiologic
responses as well as the growth of some tumors in response to estradiol stimulation. In a …

To gain insights into the possible role of oestrogen receptor (ER) β in breast carcinogenesis,
immunohistochemical analysis of ER β was performed on 512 breast specimens …

Aim: Two oestrogen receptors (ERs) have been identified to date—the “classic” ERα and the
more recently described ERβ. Although much is known about ERα at the mRNA and protein …