Activation of transcription factor NF-κB is frequently encountered in tumor cells and
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …

The ERBB or EGF receptor (EGFR) proto-oncogene family, which consists of four structurally-
related transmembrane receptors (ie, EGFR, ErbB2, ErbB3, and ErbB4), plays an etiological …

Dual inhibitors of human epidermal growth factor receptor 2 (HER2) and epidermal growth
factor receptor (EGFR) have been investigated for breast, lung, gastric, prostate, and other …

De novo and acquired resistance are major impediments to the efficacy of conventional and
targeted cancer therapy. In unselected gastric cancer (GC) patients with advanced disease …

Gliomas are the most common primary central nervous system tumours and about 55% are
glioblastoma multiforme (GBM). Between 40% and 50% of GBM have dysregulated …

Chemoresistance contributes to cancer relapse and increased mortality in a variety of
cancer types, raising a pressing need to better understand the underlying mechanism …

High-grade gliomas account for the majority of intra-axial brain tumors. Despite abundant
therapeutic efforts, clinical outcome is still poor. Thus, new therapeutic approaches are …

Importance of the field: Head and neck squamous cell carcinoma (HNSCC) is the eighth
leading cause of cancer death worldwide. Despite advances in surgery and chemoradiation …

Background In the placebo-controlled phase III SATURN study, maintenance erlotinib after
first-line chemotherapy demonstrated significantly prolonged progression-free survival (PFS) …

Our understanding of breast cancer and its therapeutic approach has improved greatly due
to the advancement of molecular biology in recent years. Clinically, breast cancers are …