It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …

The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Most genome-wide association studies (GWAS) of major depression (MD) have been
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …

Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …

The molecular diversity of glia in the human hippocampus and their temporal dynamics over
the lifespan remain largely unknown. Here, we performed single-nucleus RNA sequencing …

The question of why people show individual differences in their behaviours and capacities
has intrigued researchers for centuries. Behaviour genetics offers us various methods to …

Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …

Depression is the most prevalent mental disorder in the world associated with huge socio-
economic consequences. While depressive-related symptoms are well known, the …

Functional changes of white matter are largely unexplored in patients with psychiatric
disorders. This study examined white matter dysfunctions common in four major psychiatric …