Hearing loss caused by exposure to recreational and occupational noise remains a
worldwide disabling condition and dysregulation of redox homeostasis is the hallmark of …

Experimental and clinical data suggest a tight link between hearing and cognitive functions
under both physiological and pathological conditions. Indeed, hearing perception requires …

Platinum-based agents, such as cisplatin, form the mainstay of currently used
chemotherapeutic regimens for several malignancies; however, the main limitations are …

Several studies identified hearing loss as a risk factor for aging-related processes, including
neurodegenerative diseases, as dementia and age-related hearing loss (ARHL). Although …

Presbycusis, or age-related hearing loss (ARHL), is a major public health issue. About half
the phenotypic variance has been attributed to genetic factors. Here, we assessed the …

Background Redox imbalance and inflammation have been proposed as the principal
mechanisms of damage in the auditory system, resulting in functional alterations and …

Inherited diseases caused by connexin mutations are found in multiple organs and include
hereditary deafness, congenital cataract, congenital heart diseases, hereditary skin …

Hearing loss is the most common congenital sensory impairment. Mutations or deficiencies
of the GJB2 gene are the most common genetic cause of congenital non-syndromic …

Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been
found to be involved in multiple pathophysiological states from cancer to cardiovascular …

Connexin 26 and connexin 30 are the prevailing isoforms in the epithelial and connective
tissue gap junction systems of the developing and mature cochlea. The most frequently …