Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional
groups from the lysine residues of both histone and nonhistone proteins. In humans, there …

Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly
influenced by the post-translational modification of histones, the building blocks of …

Results From a Pivotal, Open-Label, Phase II Study of Romidepsin in Relapsed or Refractory
Peripheral T-Cell Lymphoma After Prio Page 1 Results From a Pivotal, Open-Label, Phase II …

Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Final Results from a Multicenter, International, Pivotal Study of Romidepsin in Refractory
Cutaneous T-Cell Lymphoma Page 1 Final Results from a Multicenter, International, Pivotal …

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls
angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes …

Together, histone acetyltransferases and histone deacetylases (HDACs) determine the
acetylation status of histones. This acetylation affects the regulation of gene expression, and …

The opposing actions of histone acetyltransferases (HATs) and histone deacetylases
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …

Every year more than 13 million deaths worldwide are due to environmental pollutants, and
approximately 24% of diseases are caused by environmental exposures that might be …

Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a
group of targeted anticancer agents. The first of these new HDACi, vorinostat …