Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings

M Serra, N Simola, AE Pollack… - Neural Regeneration …, 2024 - journals.lww.com
Preclinical and clinical studies indicate that psychostimulants, in addition to having abuse
potential, may elicit brain dysfunctions and/or neurotoxic effects. Central toxicity induced by …

A mechanistic overview of approaches for the treatment of psychostimulant dependence

KL Jensen, SB Jensen, KL Madsen - Frontiers in Pharmacology, 2022 - frontiersin.org
Psychostimulant use disorder is a major health issue around the world with enormous
individual, family-related and societal consequences, yet there are no effective …

Long-lasting BDNF signaling alterations in the amygdala of adolescent female rats exposed to the activity-based anorexia model

F Mottarlini, B Rizzi, G Targa, F Fumagalli… - Frontiers in Behavioral …, 2022 - frontiersin.org
Introduction: Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a
pathological fear of gaining weight, excessive physical exercise, and emotional instability …

A single dose of cocaine raises SV2A density in hippocampus of adolescent rats

R Rossi, SL Bærentzen, MB Thomsen… - Acta …, 2024 - cambridge.org
ObjectiveCocaine is a highly addictive psychostimulant that affects synaptic activity with
structural and functional adaptations of neurons. The transmembrane synaptic vesicle …

Early life adversity: Epigenetic regulation underlying drug addiction susceptibility

JJ Winter, KL Rodríguez-Acevedo, M Dittrich… - Molecular and Cellular …, 2023 - Elsevier
Drug addiction is a leading cause of disability worldwide, with more than 70,000 Americans
dying from drug overdose in 2019 alone. While only a small percentage of chronic drug …

Exploring peripheral biomarkers in psychostimulant use: a systematic review on neurotrophins, stress-related hormones, oxidative stress molecules and genetic …

M Gianluca, M Andrea, S Mario, C Clara… - Behavioural Brain …, 2024 - Elsevier
Background This systematic review aims to comprehensively explore the impact of
psychostimulant substances on neurotrophic and inflammatory pathways, including brain …

Chronic early-life lead exposure sensitizes adolescent rats to cocaine: Role of the dopaminergic system

D Albores-Garcia, KH Stansfield… - Frontiers in Molecular …, 2022 - frontiersin.org
Exposure to heavy metals has been associated with psychiatric disorders and recent studies
suggest an association between childhood lead (Pb2+) intoxication and schizophrenia (SZ) …

精神刺激剂在实验模型和人类中诱导的脑功能障碍和神经毒性: 最新发现综述

M Serra, N Simola, AE Pollack, G Costa - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
Preclinical and clinical studies indicate that psychostimulants, in addition to having abuse
potential, may elicit brain dysfunctions and/or neurotoxic effects. Central toxicity induced by …

Serum BDNF levels increase during early drug withdrawal in alcohol and crack cocaine addiction

F Ornell, JN Scherer, JB Schuch, AO Sordi, SC Halpern… - Alcohol, 2023 - Elsevier
Brain-derived neurotrophic factor (BDNF) is involved in several drug-induced brain
neuroadaptations. The impact of withdrawal from substances that have different neurological …

[PDF][PDF] Clinical Pathways Illustrating the Dangers of Drug Abuse-Induced Cognitive Behaviour Impairment

C Mathew - Int J Psychiatr Res, 2023 - scivisionpub.com
Pharmacology has risen to a new horizon with its many branches of clinical research and
practices. One among these is the field of neuro-psycho-pharmacology. Neuroscience is the …